Sherry won poster award in the 5th Asian Cardiovascular Symposium co-organized by the Academy of Cardiovascular Research Excellence, Japanese Cardiovascular Research Association, Korean Cardiovascular Society, and Society for South Asian Heart Association.
Ning has defended her PhD thesis. Congratulations, Dr. Gao!
Sherry and Ya’s paper “Thermosensitive and Antioxidant Wound Dressings Capable of Adaptively Regulating TGFβ Pathways Promote Diabetic Wound Healing” has been accepted for publication in npj Regenerative Medicine. Congratulations!
Tina won Musculoskeletal Research Center travel award for her work “Upregulating the expressions of angiogenic and myogenic factors in stem cell-derived exosomes for vascularization and muscle regeneration in ischemic hindlimbs.” Congratulations!
Guan lab attended Society for Biomaterials conference in San Diego. Jiaxing presented “Targeting Tissue-resident Macrophage Secreted MCP-1 for Attenuating Inflammation After Myocardial Infarction.”
Sherry has been promoted to Research Assistant Professor in the Department of Mechanical Engineering and Materials Science. Congratulations!
Ya’s paper “Rescuing Cardiac Cells and Improving Cardiac Function by Targeted Delivery of Oxygen-Releasing Nanoparticles after or Even before Acute Myocardial Infarction” has been published in ACS Nano. Congratulations! In this work, we demonstrated that the oxygen-releasing nanoparticles, delivered either pre-MI or post-MI, enhanced cardiac cell survival, stimulated angiogenesis, and suppressed fibrosis without inducing substantial inflammation and reactive oxygen species overproduction. These nanoparticles can provide a nonpharmacological solution to rescue the infarcted heart during acute MI and preserve heart function.
Guan lab attended BMES in San Antonio, TX. Sherry had an oral presentation entitled “Preserve and vascularize cardiac extracellular matrix after acute myocardial infarction.” Tina presented a poster entitled “Co-delivery of engineered cell membrane repair protein and mesenchymal stem cells to promote vascularization and muscle repair in ischemic hindlimbs of diabetic mice.”
Yu started her new position as a Research Scientist at Charles River Laboratories. Congratulations!
Dr. Guan has been awarded a new NIH R01. The focus of this 4-year, ~$1.9 million grant is wound healing under diabetic and aging conditions. In this project, we will develop multifunctional hydrogels and differentially control TGFβ pathway to accelerate wound closure. Dr. Liang Ma of Internal Medicine, and Dr. Mohamed Zayed of Surgery and of Radiology, are co-investigators of this grant.
Related news report:
Water-based gel to be tested as dressing for diabetic wounds
Ya started his new position as a postdoc in the Department of Biomedical Engineering at Duke University. Congratulations!
Dr. Guan (PI) and Dr. Fuzhong Zhang (MPI) have received a new NIH R01 entitled “Targeted delivery of a proangiogenic and promyogenic protein for regeneration of diabetic ischemic limbs.” This 4-year, $2.3 million grant will focus on engineering of TRIM72, and targeted delivery of the engineered protein to accelerate vascularization and muscle regeneration in diabetic ischemic limbs. Drs. Gretchen Meyer and Mohamed Zayed are co-investigators of this grant.
Related news report:
Protein-delivery undercover may regenerate obstructed arteries in limbs of diabetics
Yu and Ya successfully defended their theses. Congratulations, Drs. Dang and Guan!
Sherry and Ya’s paper “Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development” was published on Bioactive Materials.
Sherry’s paper “Delivery of VEGF and Dll4 to Synergistically Regenerate Capillaries and Arterioles in Ischemic Limbs” was published on Acta Biomaterialia.
Ya presented an oral talk at BMES in Orlando.
Sherry presented an oral talk at Center of Regenerative Medicine RAD forum.
August 28, 2021
Ya and Sherry’s paper “Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation” was published on Science Advances.
Check our findings in the news:
August 27, 2021
Oxygen-delivering hydrogel accelerates diabetic wound healing
Sherry, Yu and Ya presented oral talks at SFB annual meeting.
Ya and Ning’s paper “Oxygen-release microspheres capable of releasing oxygen in response to environmental oxygen level to improve stem cell survival and tissue regeneration in ischemic hindlimbs” was published on Journal of Controlled Release
Yu’s paper “Targeted Delivery of a Matrix Metalloproteinases-2 Specific Inhibitor Using Multifunctional Nanogels to Attenuate Ischemic Skeletal Muscle Degeneration and Promote Revascularization” was published on ACS applied materials and interfaces.
Ya’s paper “Photoluminescent oxygen-release microspheres to image the oxygen release process in vivo” was published on Acta Biomaterialia.
Dr. Guan and Dr. Jie Shen in Orthopedic Surgery have been awarded a new NIH R01 entitled “Targeting angiogenesis for fracture nonunion treatment under inflammatory diseases.” Drs. Guan and Shen are PIs of this award. This 5-year, $2.8 million grant will test the hypothesis that chronic inflammation results in fracture nonunion through Dnmt3b downregulation mediated angiogenesis defect, and local delivery of OPN and CXCL12 restores angiogenesis and fracture repair under inflammatory conditions.
May 28, 2020
Guan to serve on NIH Biomaterials and Biointerfaces Study Section
Sherry’s paper “High oxygen preservation hydrogels to augment cell survival under hypoxic condition” was published on Acta Biomaterialia.
March 31, 2020
Guan inducted into American Institute for Medical and Biological Engineering
Yu’s paper “Nanoparticle-based drug delivery systems for cancer therapy” was published on Smart Materials in Medicine.
Ya presented an oral talk at BMES in Philadelphia. Sherry and Ning presented posters.
Zhaobo’s paper “Spatiotemporal delivery of basic fibroblast growth factor to directly and simultaneously attenuate cardiac fibrosis and promote cardiac tissue vascularization following myocardial infarction” was published on Journal of Controlled Release.
Chao’s paper “Injectable Oxygen Sensitive Chitosan Complex with High Oxygen Sensitivity and Stability to Oxidoreductants” was published on ACS Biomaterials Science & Engineering.
Chao, Zheng and Ning’s paper “Injectable, thermosensitive, fast gelation, bioeliminable, and oxygen sensitive hydrogels” was published on Materials Science and Engineering: C.
Yu presented oral talks at SFB annual meeting in Seattle. Sherry and Ya presented posters. Yu also won a STAR award!
February 22, 2019
Engineer to develop a drug-filled gel to repair heart after heart attack
Sherry presented an oral talk at Musculoskeletal Winter Symposium and won a travel award!
Dr. Guan has been awarded a four-year, $1.8 million grant from the National Institutes of Health’s National Heart, Lung, and Blood Institute. This grant aims to develop a new hydrogel-based drug delivery system that can be directly applied to the damaged part of the heart after myocardial infarction (or heart attack) to decrease MMP-2/9 activity, preserve cardiac extracellular matrix, and vascularize the preserved extracellular matrix.
Sherry’s paper “Thermosensitive, fast gelling, photoluminescent, highly flexible, and degradable hydrogels for stem cell delivery” was published on Acta Biomaterialia.
Prof. Guan joined the Department of Mechanical Engineering and Materials Science at WashU