August 2023
Sherry won poster award in the 5th Asian Cardiovascular Symposium co-organized by the Academy of Cardiovascular Research Excellence, Japanese Cardiovascular Research Association, Korean Cardiovascular Society, and Society for South Asian Heart Association.
June 2023
Ning has defended her PhD thesis. Congratulations, Dr. Gao!
June 2023
Sherry and Ya’s paper “Thermosensitive and Antioxidant Wound Dressings Capable of Adaptively Regulating TGFβ Pathways Promote Diabetic Wound Healing” has been accepted for publication in npj Regenerative Medicine. Congratulations!
May 2023
Tina won Musculoskeletal Research Center travel award for her work “Upregulating the expressions of angiogenic and myogenic factors in stem cell-derived exosomes for vascularization and muscle regeneration in ischemic hindlimbs.” Congratulations!
April 2023
Guan lab attended Society for Biomaterials conference in San Diego. Jiaxing presented “Targeting Tissue-resident Macrophage Secreted MCP-1 for Attenuating Inflammation After Myocardial Infarction.”
December 2022
Sherry has been promoted to Research Assistant Professor in the Department of Mechanical Engineering and Materials Science. Congratulations!
November 2022
Ya’s paper “Rescuing Cardiac Cells and Improving Cardiac Function by Targeted Delivery of Oxygen-Releasing Nanoparticles after or Even before Acute Myocardial Infarction” has been published in ACS Nano. Congratulations! In this work, we demonstrated that the oxygen-releasing nanoparticles, delivered either pre-MI or post-MI, enhanced cardiac cell survival, stimulated angiogenesis, and suppressed fibrosis without inducing substantial inflammation and reactive oxygen species overproduction. These nanoparticles can provide a nonpharmacological solution to rescue the infarcted heart during acute MI and preserve heart function.
October 2022
Guan lab attended BMES in San Antonio, TX. Sherry had an oral presentation entitled “Preserve and vascularize cardiac extracellular matrix after acute myocardial infarction.” Tina presented a poster entitled “Co-delivery of engineered cell membrane repair protein and mesenchymal stem cells to promote vascularization and muscle repair in ischemic hindlimbs of diabetic mice.”
October 2022
Yu started her new position as a Research Scientist at Charles River Laboratories. Congratulations!
August 2022
Dr. Guan has been awarded a new NIH R01. The focus of this 4-year, ~$1.9 million grant is wound healing under diabetic and aging conditions. In this project, we will develop multifunctional hydrogels and differentially control TGFβ pathway to accelerate wound closure. Dr. Liang Ma of Internal Medicine, and Dr. Mohamed Zayed of Surgery and of Radiology, are co-investigators of this grant.
Related news report:
Water-based gel to be tested as dressing for diabetic wounds
July 2022
Ya started his new position as a postdoc in the Department of Biomedical Engineering at Duke University. Congratulations!
May 2022
Dr. Guan (PI) and Dr. Fuzhong Zhang (MPI) have received a new NIH R01 entitled “Targeted delivery of a proangiogenic and promyogenic protein for regeneration of diabetic ischemic limbs.” This 4-year, $2.3 million grant will focus on engineering of TRIM72, and targeted delivery of the engineered protein to accelerate vascularization and muscle regeneration in diabetic ischemic limbs. Drs. Gretchen Meyer and Mohamed Zayed are co-investigators of this grant.
Related news report:
Protein-delivery undercover may regenerate obstructed arteries in limbs of diabetics
April 2022
Yu and Ya successfully defended their theses. Congratulations, Drs. Dang and Guan!
March 2022
Sherry and Ya’s paper “Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development” was published on Bioactive Materials.
March 2022
Sherry’s paper “Delivery of VEGF and Dll4 to Synergistically Regenerate Capillaries and Arterioles in Ischemic Limbs” was published on Acta Biomaterialia.
October 2021
Ya presented an oral talk at BMES in Orlando.
September 2021
Sherry presented an oral talk at Center of Regenerative Medicine RAD forum.
August 28, 2021
Ya and Sherry’s paper “Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation” was published on Science Advances.
Check our findings in the news:
https://newatlas.com/medical/oxygen-hydrogel-chronic-wounds/
https://www.miragenews.com/oxygen-delivering-hydrogel-accelerates-diabetic-622500/
August 27, 2021
Oxygen-delivering hydrogel accelerates diabetic wound healing
April 2021
Sherry, Yu and Ya presented oral talks at SFB annual meeting.
March 2021
Ya and Ning’s paper “Oxygen-release microspheres capable of releasing oxygen in response to environmental oxygen level to improve stem cell survival and tissue regeneration in ischemic hindlimbs” was published on Journal of Controlled Release
February 2021
Yu’s paper “Targeted Delivery of a Matrix Metalloproteinases-2 Specific Inhibitor Using Multifunctional Nanogels to Attenuate Ischemic Skeletal Muscle Degeneration and Promote Revascularization” was published on ACS applied materials and interfaces.
October 2020
Ya’s paper “Photoluminescent oxygen-release microspheres to image the oxygen release process in vivo” was published on Acta Biomaterialia.
September 2020
Dr. Guan and Dr. Jie Shen in Orthopedic Surgery have been awarded a new NIH R01 entitled “Targeting angiogenesis for fracture nonunion treatment under inflammatory diseases.” Drs. Guan and Shen are PIs of this award. This 5-year, $2.8 million grant will test the hypothesis that chronic inflammation results in fracture nonunion through Dnmt3b downregulation mediated angiogenesis defect, and local delivery of OPN and CXCL12 restores angiogenesis and fracture repair under inflammatory conditions.
May 28, 2020
Guan to serve on NIH Biomaterials and Biointerfaces Study Section
March 2020
Sherry’s paper “High oxygen preservation hydrogels to augment cell survival under hypoxic condition” was published on Acta Biomaterialia.
March 31, 2020
Guan inducted into American Institute for Medical and Biological Engineering
January
Yu’s paper “Nanoparticle-based drug delivery systems for cancer therapy” was published on Smart Materials in Medicine.
October 2019
Ya presented an oral talk at BMES in Philadelphia. Sherry and Ning presented posters.
October 2019
Zhaobo’s paper “Spatiotemporal delivery of basic fibroblast growth factor to directly and simultaneously attenuate cardiac fibrosis and promote cardiac tissue vascularization following myocardial infarction” was published on Journal of Controlled Release.
May 2019
Chao’s paper “Injectable Oxygen Sensitive Chitosan Complex with High Oxygen Sensitivity and Stability to Oxidoreductants” was published on ACS Biomaterials Science & Engineering.
September 2019
Chao, Zheng and Ning’s paper “Injectable, thermosensitive, fast gelation, bioeliminable, and oxygen sensitive hydrogels” was published on Materials Science and Engineering: C.
April 2019
Yu presented oral talks at SFB annual meeting in Seattle. Sherry and Ya presented posters. Yu also won a STAR award!
February 22, 2019
Engineer to develop a drug-filled gel to repair heart after heart attack
February 2019
Sherry presented an oral talk at Musculoskeletal Winter Symposium and won a travel award!
January 2019
Dr. Guan has been awarded a four-year, $1.8 million grant from the National Institutes of Health’s National Heart, Lung, and Blood Institute. This grant aims to develop a new hydrogel-based drug delivery system that can be directly applied to the damaged part of the heart after myocardial infarction (or heart attack) to decrease MMP-2/9 activity, preserve cardiac extracellular matrix, and vascularize the preserved extracellular matrix.
January 2019
Sherry’s paper “Thermosensitive, fast gelling, photoluminescent, highly flexible, and degradable hydrogels for stem cell delivery” was published on Acta Biomaterialia.
August 2018
Prof. Guan joined the Department of Mechanical Engineering and Materials Science at WashU