Welcome to the Polymeric Biomaterials
and Regenerative Medicine Laboratory
Our research is mainly focused on functional biomaterials and microenvironments for cell and drug delivery; oxygen sensitive biomaterials for non-invasively and real time imaging and detecting tissue oxygen during vascularization therapy; and cardiovascular, skin, and musculoskeletal tissue regeneration. Our research covers regenerative medicine, polymer, drug delivery, nanomedicine, stem cell, biomechanics, surgery, and biomedical imaging fields.
Our projects include: development of biomimetic elastic polymers; generation and mathematical modeling of nano-structured scaffolds mimicking biomechanical and structural properties of tissues; synthesis of injectable, fast gelation, highly flexible, and smart hydrogels for cell and drug therapies; development of polymeric, degradable, and imageable electron paramagnetic resonance (EPR) probes and magnetic resonance imaging (MRI) probes for real time oxygen detection in tissues; design of novel proteins/peptides and their delivery systems to control tissue fibrosis and extracellular matrix (ECM) degradation, decrease tissue inflammation, and promote fast angiogenesis during cardiac repair, wound healing, and ischemic limb regeneration; engineering of microenvironments to harness stem cell secretome; development of multifunctional stem cell and stem cell-derived-secretome delivery systems for myocardial, ischemic limb, and bone regeneration; engineering of cardiac patches capable of fast angiogenesis; and elucidating mechanisms of stem cell fate determination by biomaterials.
